Organic / Synthetic Chemistry
Dr Rousseau is a senior lecturer at the University of the Witwatersrand, South Africa. Her research focuses on the design and synthesis of compounds with the potential to display anti-malarial activity. Her recent work has focused on the use of kinase inhibitors to prevent malaria transmission, with a particular emphasis on the use of the parasite’s arsenal of enzymes to synthesise potent anti-folates from advanced precursors in situ. Another area of interest is the use of multi-component coupling reactions to synthesise complex molecules in a single transformation. This strategy is currently being employed in the synthesis of spiroindolones as potential antimalarial agents.
TITLE: Small molecule inhibitors of Plasmodium falciparum
DATE: 29 August 2016