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September 30, 2015

Scientists discover new system for human genome editing

Game-changing technology could disrupt both scientific, commercial landscape A team including the scientist who first harnessed the revolutionary CRISPR-Cas9 system for mammalian genome editing has now identified a different CRISPR system with the potential for even simpler and more precise genome engineering. In a study published in Cell, Feng Zhang […]
September 30, 2015

African Leaders, International Partners Launch New Initiatives to Spur Scientific Research in Africa

African and international partners launched the Alliance for Accelerating Excellence in Science in Africa (AESA), a new initiative that aims to help drive Africa’s research agenda and build scientific capacity across the continent. AESA was created by the African Academy of Sciences (AAS) and the New Partnership for Africa’s Development […]
July 31, 2015

Dereplicating and spatial mapping of secondary metabolites from fungal cultures in situ

VP Sica, HA Raja, T El-Elimat, V Kertesz, GJ Van Berkel, CJ Pearce, NH Oberlies. Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00268, 2015 35.00 USD Ambient ionization mass spectrometry techniques have recently become prevalent in natural product research due to their ability to examine secondary metabolites in situ. These techniques retain […]
July 31, 2015

Combining mass spectrometric metabolic profiling with genomic analysis: a powerful approach for discovering natural products from Cyanobacteria

K Kleigrewe, J Almaliti, IY Tian, RB Kinnel, A Korobeynikov, EA Monroe, BM Duggan, V Di Marzo, DH Sherman, PC Dorrestein, L Gerwick, WH Gerwick. Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b0030, 2015 35.00 USD An innovative approach was developed for the discovery of new natural products by combining mass spectrometric […]
July 31, 2015

A new NMR approach for structure determination of thermally unstable biflavanones and application to phytochemicals from Garcinia buchananii

TD Stark, S Lösch, M Salger, OB Balemba, J Wakamatsu, O Frank,T Hofmann. Magnetic Resonance in Chemistry DOI 10.1002/mrc.4269, 2015 38.00 USD Previous activity-guided phytochemical studies on Garcinia buchananii stem bark, which is traditionally used in Africa to treat various gastrointestinal and metabolic illnesses, revealed xanthones, polyisoprenylated benzophenones, flavanone-C-glycosides, biflavonoids, […]