Selected Journal Articles

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September 30, 2015

Design and Synthesis of α-Carboxy Nucleoside Phosphonate Analogues and Evaluation as HIV-1 Reverse Transcriptase-Targeting Agents

SJ Keane, A Ford, ND Mullins, NM Maguire, T Legigan, J Balzarini, AR Maguire. Journal of Organic Chemistry, 6(5):2479-2493. 2015 The synthesis of the first series of a new class of nucleoside phosphonate analogues is described. Addition of a carboxyl group at the α position of carbocyclic nucleoside phosphonate analogues […]
September 30, 2015

Biochemical characterization and pharmacognostic evaluation of purified catechins in green tea (Camellia sinensis) cultivars of India

J Anand, B Upadhyaya, P Rawat, N Rai. doi: 10.1007/s13205-014-0230-0 Green tea (GT) is derived from the leaves of Camellia sinensis implicated in a wide range of health attributes. In the present comprehensive study, methanolic, acetone and aqueous extract of leaves of C. sinensis var. sinensis [Kashmir (KW), Uttarakhand (IP […]
July 31, 2015

Dereplicating and spatial mapping of secondary metabolites from fungal cultures in situ

VP Sica, HA Raja, T El-Elimat, V Kertesz, GJ Van Berkel, CJ Pearce, NH Oberlies. Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00268, 2015 35.00 USD Ambient ionization mass spectrometry techniques have recently become prevalent in natural product research due to their ability to examine secondary metabolites in situ. These techniques retain […]
July 31, 2015

Combining mass spectrometric metabolic profiling with genomic analysis: a powerful approach for discovering natural products from Cyanobacteria

K Kleigrewe, J Almaliti, IY Tian, RB Kinnel, A Korobeynikov, EA Monroe, BM Duggan, V Di Marzo, DH Sherman, PC Dorrestein, L Gerwick, WH Gerwick. Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b0030, 2015 35.00 USD An innovative approach was developed for the discovery of new natural products by combining mass spectrometric […]
July 31, 2015

A new NMR approach for structure determination of thermally unstable biflavanones and application to phytochemicals from Garcinia buchananii

TD Stark, S Lösch, M Salger, OB Balemba, J Wakamatsu, O Frank,T Hofmann. Magnetic Resonance in Chemistry DOI 10.1002/mrc.4269, 2015 38.00 USD Previous activity-guided phytochemical studies on Garcinia buchananii stem bark, which is traditionally used in Africa to treat various gastrointestinal and metabolic illnesses, revealed xanthones, polyisoprenylated benzophenones, flavanone-C-glycosides, biflavonoids, […]